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- In a San Francisco hospital two doctors, Rae Brennan and Matt Slingerland, try to break away from paperwork combined with impersonal care. With other colleagues they try to give their patients their full attention.
- A defeated senator returns home to reconnect with his three grown daughters.
- Lanning and Keating treat a trouble young girl who wants to be sterilized; Jordan and her physician husband clash with how to get the mother of an obese boy to take her son's health seriously.
- Collette treats a firefighter with serious burns; Brennan refocuses on making her marriage work and ending her affair with Dr. Kokoris.
- Rae tries to persuade the parents of a boy with sickle-cell anemia to tell him he has the disease; Matt agrees to donate sperm to fertilize Jules' eggs; Harriet attempts to convince a woman with heart problems to deliver her baby early.
- Lanning and Keating work together to save the life of a newborn baby; Keating faces a medical scare that could prevent her from having children; Brennan helps a man whose father has cancer deal with his impending death.