The Best Female-Lead Comedy TV Shows of the 21st Century
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- CreatorDavid E. KelleyStarsCalista FlockhartGreg GermannJane KrakowskiFollows the personal and professional life of lawyer Ally.
- CreatorDarren StarStarsSarah Jessica ParkerKim CattrallKristin DavisFour female New Yorkers gossip about their sex lives (or lack thereof) and find new ways to deal with being a woman in the late 1990s.
- CreatorStephen ColbertPaul DinelloMitch RouseStarsAmy SedarisPaul DinelloStephen ColbertA 46-year-old ex-drug addict returns to high school as a freshman.
- CreatorAmy Sherman-PalladinoStarsLauren GrahamAlexis BledelKeiko AgenaA dramedy centering around the relationship between a thirtysomething single mother and her teen daughter living in Stars Hollow, Connecticut.
- CreatorAllison M. GibsonStarsReba McEntireJoAnna Garcia SwisherSteve HoweyReba McEntire stars as the titular character in this smash sitcom about a single mom of three, navigating life in a Houston suburb.
- CreatorBryan FullerStarsEllen MuthCallum BlueJasmine GuyAfter being hit on the head by a toilet seat that fell from Mir space station, a young temp clerk becomes a grim reaper in death.
- CreatorBryan FullerTodd HollandStarsCaroline DhavernasKatie FinneranTyron Leitso24-year-old loner B.A. Jaye lives in a trailer park and sells souvenirs in Niagara Falls. Animal figurines and dolls speak to her and force her to interact with people and try to help them.
- CreatorMarc CherryStarsTeri HatcherFelicity HuffmanMarcia CrossSecrets and truths unfold through the lives of female friends in one suburban neighborhood after the mysterious suicide of a neighbor.
- CreatorMichael Patrick KingLisa KudrowStarsLisa KudrowLance BarberRobert Michael MorrisAn ex A-list celebrity attempts to rekindle the flame of her once prominent acting career with nothing but a camera crew and some determination.
- CreatorJenji KohanStarsMary-Louise ParkerHunter ParrishAlexander GouldWhen a suburban mother turns to dealing marijuana in order to maintain her privileged lifestyle after her husband dies, she finds out just how addicted her entire neighborhood already is.
- CreatorTina FeyStarsTina FeyAlec BaldwinTracy MorganLiz Lemon, head writer of the sketch-comedy show "TGS with Tracy Jordan", must deal with an arrogant new boss and a crazy new star while trying to run a successful television show without losing her mind.
- CreatorChris AlberghiniMike ChesslerTori SpellingStarsTori SpellingZachary QuintoJames CarpinelloA parody of the life of Tori Spelling, by Tori Spelling.
- CreatorFernando GaitánSilvio HortaStarsAmerica FerreraEric MabiusTony PlanaSmart but wholesome Betty embraces her unique appearance and independent attitude in the cutthroat world of New York fashion.
- CreatorCecelia AhernDonald ToddStarsChristina ApplegateJennifer EspositoKevin DunnA woman suffers from amnesia and is forced to find out who she really is.
- CreatorDan HarmonRob SchrabSarah SilvermanStarsSarah SilvermanLaura SilvermanBrian PosehnSarah's immature, only thinks of herself and has no inhibition nor work. Her sister Laura pays her rent. She has a gay couple as neighbors. Laura's seeing cop Jay.
- CreatorGreg DanielsMichael SchurStarsAmy PoehlerJim O'HeirNick OffermanThe absurd antics of an Indiana town's public officials as they pursue sundry projects to make their city a better place.
- CreatorLiz BrixiusEvan DunskyLinda WallemStarsEdie FalcoMerritt WeverPaul SchulzeA drug-addicted nurse struggles to find a balance between the demands of her frenetic job at a New York City hospital and an array of personal dramas.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorDiablo CodyStarsToni ColletteJohn CorbettRosemarie DeWittA woman struggles to find a balance between her dissociative identity disorder and raising a dysfunctional family.
- CreatorJosh BermanStarsBrooke ElliottMargaret ChoKate LeveringA vapid aspiring model killed in a car crash gets brought back to life as an intelligent, overweight lawyer, hoping to find the meaning of inner beauty.
- CreatorDarlene HuntStarsLaura LinneyOliver PlattGabriel BassoA suburban mother faces her cancer diagnosis while trying to find humor and happiness as well.
- CreatorLauren IungerichStarsAshley RickardsBeau MirchoffJillian Rose ReedAn unpopular 15-year-old gains immediate, yet unwanted, popularity at her high school when the student body mistakes an accident she has for a suicide attempt.
- CreatorElizabeth MeriwetherStarsZooey DeschanelJake JohnsonMax GreenfieldAfter a bad break-up, Jess, an offbeat young woman, moves into an apartment loft with three single men. Although they find her behavior very unusual, the men support her - most of the time.
- CreatorWhitney CummingsMichael Patrick KingStarsKat DenningsBeth BehrsGarrett MorrisTwo young women waitressing at a greasy spoon diner strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.
- CreatorLaura DernMike WhiteStarsLaura DernDiane LaddSarah BurnsA self-destructive woman who has a spiritual awakening becomes determined to live an enlightened life, creating havoc at home and work.
- CreatorMindy KalingStarsMindy KalingIke BarinholtzEd WeeksA young Ob/Gyn doctor balances her personal and professional life, surrounded by quirky co-workers in a small office.
- CreatorArmando IannucciStarsJulia Louis-DreyfusTony HaleAnna ChlumskyFormer Senator Selina Meyer finds that being Vice President of the United States is nothing like she hoped and everything that everyone ever warned her about.
- CreatorLena DunhamStarsLena DunhamAllison WilliamsJemima KirkeA comedy about the experiences of a group of girls in their early 20s.
- CreatorNahnatchka KhanStarsKrysten RitterDreama WalkerMichael BlaiklockChloe is a New York party girl with the morals of a pirate. She causes trouble for her best friend James Van Der Beek and her naive small-town roommate June.
- CreatorTheresa RebeckStarsDebra MessingJack DavenportKatharine McPheeMore drama occurs behind the scenes than on stage, as the team prepares an ambitious Broadway musical on the life of Marilyn Monroe.
- CreatorDaniel PowellAmy SchumerStarsAmy SchumerKevin KaneKyle DunniganAmy Schumer switches from sketches to doing stand-up to interviewing people on the street and people of interest, usually following a certain theme.
- CreatorGemma BakerEddie GorodetskyChuck LorreStarsAllison JanneyAnna FarisMimi KennedyA newly sober single mom tries to pull her life together in Napa Valley while dealing with her wayward mother.
- CreatorEmily HalpernSarah HaskinsStarsMalin AkermanBradley WhitfordMichaela WatkinsA reformed party girl finds herself an insta-family after falling in love with a man with three manipulative children and two judgmental ex-wives.
- CreatorJenji KohanStarsTaylor SchillingDanielle BrooksTaryn ManningConvicted of a decade-old crime of transporting drug money, ordinarily law-abiding Piper Chapman is sentenced to 18 months behind bars and quickly discovers the realities of life-changing prison time.
- CreatorJo BrandMark V. OlsenStarsLaurie MetcalfAlex BorsteinNiecy NashCranky nurses, anxious doctors, and administrators wrestle with the darkly comic, honest, and compassionate realities of caring for the elderly in a rundown hospital.
- CreatorMarc CherryStarsAna OrtizDania RamirezRoselyn SanchezFour Latina maids with ambition and dreams of their own work for the rich and famous in Beverly Hills.
- CreatorJennie Snyder UrmanStarsGina RodriguezAndrea NavedoYael GrobglasA young, devout Catholic woman discovers that she was accidentally artificially inseminated.
- CreatorIlana GlazerAbbi JacobsonStarsIlana GlazerAbbi JacobsonHannibal BuressBroad City follows two women throughout their daily lives in New York City, making the smallest and mundane events hysterical and disturbing to watch all at the same time.
- CreatorLennon ParhamJessica St. ClairStarsLennon ParhamJessica St. ClairKeegan-Michael KeyChildhood best friends Maggie Caruso and Emma Crawford have shared countless adventures growing up together. Now, Maggie and Emma are in store for one of their biggest adventures - raising a baby.
- CreatorCarter CovingtonDana GoodmanJulia Lea WolovStarsRita VolkKatie StevensGregg SulkinAfter numerous attempts of trying to be popular two best friends decide to come out as lesbians, which launches them to instant celebrity status. Seduced by their newfound fame, Karma and Amy decide to keep up their romantic ruse.
- CreatorRachel BloomAline Brosh McKennaStarsRachel BloomDonna Lynne ChamplinVincent Rodriguez IIIA young woman abandons a choice job at a law firm and her life in New York in an attempt to find happiness in the unlikely locale of West Covina, California.
- CreatorMarta KauffmanHoward J. MorrisStarsJane FondaLily TomlinSam WaterstonFinding out that their husbands are not just work partners, but have also been romantically involved for the last twenty years, two women with an already strained relationship try to cope with the circumstances together.
- CreatorRobert CarlockTina FeyStarsEllie KemperJane KrakowskiTituss BurgessA woman is rescued from a doomsday cult and starts life over again in New York City.
- CreatorDarren StarStarsSutton FosterHilary DuffDebi MazarAfter being mistaken for younger than she really is, a single mother decides to take the chance to reboot her career and her love life as a 26-year old.
- CreatorPam BradyMitchell HurwitzStarsMaria BamfordFred MelamedMary Kay PlaceSeries is based on what Maria has accepted to be "her life." The occasionally surreal episodes, refracted across multiple periods of the actor/comedian's life, tell the story of a woman who loses - and then finds - herself.