After a car wreck on Mulholland Drive renders a woman amnesiac, she and a Hollywood-hopeful search for clues and answers across Los Angeles in a twisting venture beyond dreams and reality.
A Victorian surgeon rescues a heavily disfigured man who is mistreated while scraping a living as a side-show freak. Behind his monstrous façade, there is revealed a person of kindness, intelligence and sophistication.
Two FBI agents attempt to clarify the murders occurring in a desolate region. They approach the witnesses of the latest incident with the help of the local police. All of them hide something and all have wildly different stories to tell.