- Was once pulled over by a police officer for a "rolling stop" violation. When asked to step out of the vehicle, she responded, "No". The officer asked why, and she told him that she had no pants on. He shined his flashlight in to see and responded, "Oh!". Her pants and blouse were in the trunk along with her driver's license, which the officer initially wanted to see. It turned out that before she got in the car, she had accidentally sat on some fire ants and had to strip to her bra and panties to get them off her. She told this story when she appeared on Episode #7.92 (1999) of The Tonight Show with Jay Leno.
- "Discovered" by David Hasselhoff on an airline flight.
- When she was 15 years old and in the 10th grade, she won the national cover-girl contest for Seventeen magazine (1987).
- Named an ambassador of the United Nations Children's Fund (UNICEF). (January 2013)
- When Harmon appeared on Episode #8.43 (2000), her then-boyfriend, New York Giants football player Jason Sehorn, walked out onstage and proposed during the program. Harmon accepted, and her father then came out as well to give his blessing. The proposal had been arranged by Sehorn and the Tonight Show staff.
- Has three daughters with her ex-husband Jason Sehorn: Finley Faith Sehorn (born October 14, 2003 in Dallas, Texas), Avery Grace Sehorn (born June 21, 2005 in Dallas, Texas) and Emery Hope Sehorn (born December 18, 2008).
- Met her husband, New York Giants All-Pro defensive back Jason Sehorn, after she attended a Giants football game.
- Was offered the role of Trinity in The Matrix (1999) but declined.
- Angie's father has English, as well as German, Irish, Scottish, Welsh, and remote Dutch, ancestry. Angie's maternal grandparents were both of Greek descent.
- Is a practitioner of Taekwondo & Boxing.
- She played a detective on Women's Murder Club (2007). Some of the plots were reused on Rizzoli & Isles (2010).
- No relation to Mark Harmon. However, both have co-starred with Sasha Alexander on television series.
- Is a fifth cousin many times removed of President Andrew Johnson.
- As Jane Rizzoli (Rizzoli & Isles (2010)), Angie Harmon reveals she is left-handed. For example, she carries her handgun on her left side, she shoots left-handed, and she wears her wristwatch on her right wrist.
- Has played both sides of the Law & Order (1990) dynamic. She played ADA Abbie Carmichael on Law & Order (1990) (1998-2001) and Detective Jane Rizzoli on Rizzoli & Isles (2010).
- Attended the same high school as Law & Order: Special Victims Unit (1999) cast member Stephanie March. Angie was a senior when Stephanie was a freshman.
- Her parents, Lawrence Paul Harmon and Daphne Demar Caravageli, were both models. They divorced when she was still a toddler.
- Spoke at the Republican National Convention with her now ex-husband, Jason Sehorn, on August 30, 2004.
- Attended and graduated from Highland Park High School in University Park, Texas (1990).
- She is a registered Republican, and endorsed both John McCain for the 2008 presidential election and Mitt Romney for the 2012 presidential election.
- Good friends with Garcelle Beauvais.
- Related to Pleasant Wayne, by marriage of their first cousins.
- In Glass House: The Good Mother (2006), she slaps twice Jordan Danger.
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