- He is considered the Brazilian version of Walt Disney.
- He inspired his characters in his personal influences in real life like his daughters Mônica and Magali and his child friend Cebolinha.
- The most important and one of the most recognized cartoonists in Brazil, with Turma da Mônica (Mônica's Gang) he took the real animation to Brazil.
- Father, with his first wife, of Mariângela Spada e Sousa, Mônica, Magali Spada e Sousa and Maurício Spada e Sousa.
- Father, with an ex-girlfriend, of twins Valéria and Vanda Signorelli e Sousa.
- Father, with an ex-girlfriend, of Marcelo de Sousa.
- Father, with wife Alice, of Marina, Mauro and Maurício Takeda de Sousa.
- He and Alice have been together for 24 years now (2007). They got back together in 2005 after 7 years apart.
- Grandfather of eleven.
- Son of Petronilha Araújo de Sousa and Antônio Maurício de Sousa.
- His son Mauricio Spada died from a heart attack at the age of 44.(05/02/2016).
- His most popular character Monica was not the first to be published - this position is held by Blu and Frankin.
- Created his very first comic book character aged 12, Captain Popsicle. This character has been featured in his "Mônica" comics.
- A reason his core three characters of Monica, Maggy and Smudge (Jimmy Five wears shoes) are drawn barefoot, but with no toes was the growing necessity of drawing them with less details, as Sousa's working demand increased when publishing was starting. Monica's original look, for instance, featured shoes and pockets.
- Ten of his "Monica" characters were created based on his ten children, starting with Monica herself, who is based on his daughter. Others are based on childhood friends.
- Worked as a criminal journalist for five years.
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