- Aunt of Emily Stevens.
- She starred as Becky Sharp in the original 1899 production of Langdon Mitchell's "Becky Sharp", which would become the first three-color Technicolor film in 1935 (Becky Sharp (1935)), starring Miriam Hopkins. However, Mrs. Fiske repeated her own stage performance as Becky in the film Vanity Fair (1915), the play on which the play and film of "Becky Sharp" had been based.
- At the time of her death was considered one of America's greatest actresses.
- Her father was a prominent Southern theater manager and her mother was the daughter of an English musician and concert master.
- Made her stage debut at the age of four.
- Along with her husband Harrison Grey Fiske, she was instrumental in breaking up the "Theater Trust" (or theatrical syndicate) that controlled almost every theater in America in the late 19th and early 20th centuries.
- Her future husband Harrison Grey Fiske saw her for the first time playing a boy in the play "King John", she was eight and he was 13. They would not be formally introduced for another 11 years.
- Her husband Harrison Grey Fiske leased the Manhattan Theatre in 1901 and formed the Manhattan Company. The company included such actors as George Arliss John Mason, and Tyrone Power Sr..
- Adopted a 13-month-old baby while in her late 50s.
- Was a supporter of child welfare and animal rights causes.
- Aunt of Robert Kellard.
- Aunt of Richard Fiske.
- Fiske was a cousin to Elizabeth Maddern, the first wife of the author Jack London (1876 -1916).
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