- Member of Omega Psi Phi Fraternity, Inc.
- Received a General Educational Development (GED) after being kicked out of high school.
- He and fellow "Original Kings of Comedy" comic/friend Steve Harvey, share the distinction of a cast member from "The Jeffersons" having made guest appearances on their self-titled sitcoms as their TV mothers: Marla Gibbs, played D.L. Hughley's mother (and in the movie "The Brothers" as well), and Isabel Sanford, played Steve Harvey's mother.
- Friends with Bernie Mac, Steve Harvey, Cedric The Entertainer, Guy Torry, Luenell, Eddie Griffin, George Lopez, and Charlie Murphy.
- Father, with Ladonna Hughley of daughters Ryan Hughley (Ryan Nicole - b. 1987) and Tyler Hughley (Tyler Whitney - b. 1991), and son Kyle Hughley (Kyle Aaris - b. 1988).
- Parents are Charles Hughley and Audrey Hughley.
- Grandfather of Nola Ray Shephard.
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