- Shortly after her father Robert Kardashian's death from cancer, she was diagnosed with skin cancer. She told about her cancer diagnosis for the first time only in August 2008 and said that she fully recovered from the disease.
- Khloe's father was diagnosed with esophageal cancer only eight weeks before he passed away. The stress following her father's death caused Khloe's hair to fall out and she needed to wear wigs and extensions for awhile.
- At the age of 17, Khloe was in a serious car accident in which she flew through the front windshield of her car. She suffered brain damage and memory loss. Khloe continues to battle with issues regarding memory retention.
- It was in Khloe's bedroom that O.J. Simpson threatened to commit suicide, not sister Kim's as was erroneously depicted in American Crime Story (2016).
- Due to insufferable bullying during her high school years, Khloe moved to homeschooling, where she graduated with honors at the age of 17. Another reason she decided to leave school was that she felt herself going down the wrong path after her sisters graduated, and she didn't want to get mixed up with the wrong crowd.
- E! paid for her entire wedding. Khloe and Lamar Odom walked down the aisle one month after meeting for the first time and becoming a couple. The wedding cost approximately 1 million dollars.
- In protest of those who wear fur, Khloe posed nude for PETA in 2008, stating that she no longer had the desire to wear fur after learning about the practices involved in its manufacturing.In fact, Khloe created an entire campaign with PETA called "I'd Rather Go Naked than Wear Fur.".
- Goddaughter of Sugar Ray Leonard.
- Was handpicked by Simon Cowell to co-host the second season of The X Factor (2011) along with Mario Lopez.
- Arrested for DUI, was shown on her reality show, Keeping Up with the Kardashians (2007).
- Khloe had trouble fitting in at Marymount High School, a catholic all-girls school in Bel Air that has a lot of famous alumni, including Mariska Hargitay, Tatyana Ali, Mia Farrow, Giada De Laurentiis and Marié Digby. She dropped out and started doing home school instead and ended up graduating with honors, when she was 17 years old.
- Khloe and Lamar Odom adopted a boxer puppy in March 2013, shortly before their separation. She named the puppy BHop after the boxer, Bernard Hopkins. As of 2014, the dog lives with Khloe's assistant.
- Godmother of her niece North West.
- Runs upscale women's clothing store, Dash, with her sisters Kim and Kourtney.
- On Oct. 9, 2009, Khloe officially changed her name from Khloe Alexandra Kardashian to Khloe Kardashian Odom in Los Angeles, CA.
- Khloe and Lamar Odom made $300,000 from their wedding, after selling the exclusive rights of their wedding photos to OK! Magazine.
- Khloe spent three hours in jail after receiving a DUI in March 2007. Her early release was due to overcrowding. Her sentence was to spend 30 days in jail and attend an alcohol treatment program.
- Listed Troop Beverly Hills (1989), Welcome to the Dollhouse (1995), How to Marry a Millionaire (1953), Some Like It Hot (1959), Pillow Talk (1959), Bye Bye Birdie (1963), Moulin Rouge! (2001), Love Story (1970), and Newsies (1992) as her top movies to watch.
- At the time the Kardashian sisters appeared on the reality show, they were running their clothing store in Calabasas called DASH. Since the success of the show, they have opened up two more stores in Miami and New York. They also having a clothing line called Kardashian Kollection at Sears.
- Her father was of Armenian descent. Her mother has English, Scottish, Irish, German, Dutch, Scots-Irish/Northern Irish, Welsh, and remote Jersey Channel Islander and Cornish, ancestry.
- Khloe has fertility issues which were shared on their reality show. She was seen going to a fertility doctor who told her she had a low egg count.
- Khloe's biggest fears are whales and belly buttons.
- Daughter of Robert Kardashian and Kris Jenner. Sister of Kim Kardashian, Kourtney Kardashian, and Rob Kardashian. Half-sister of Kendall Jenner, and Kylie Jenner. Granddaughter of Mary Houghton, and Arthur Kardashian.
- Her parents divorced when she was just five years old.
- Her denim apparel generated $1 million in revenue in it's first day in October.
- Has a daughter: True Thompson (b. April 12, 2018) and son Tatum Robert (August 28, 2022)., with ex-boyfriend, Tristan Thompson.
- Good friends with Rachel Roy.
- Co-hostess, with Kim Kardashian and Kourtney Kardashian, of an infomercial for their "Perfect Skin" skin care system. Also appearing are Mario Lopez and Andie Jordan. (2010)
- She married Los Angeles Lakers pro basketball forward Lamar Odom on Sept. 27, 2009, after just one month of dating. The engagement and wedding were all filmed for their reality TV show.
- Earned an estimated $15 million, putting her in fourth place on the Forbes list of highest-earning reality stars of 2016. Her sisters Kim Kardashian, Kylie Jenner and Kendall Jenner placed first, second and third.
- Loves the color purple.
- Former daughter-in-law of Joe Odom.
- The launching of her new denim apparel was the biggest opening for a new clothing line for the month of October.[2016].
- The majority of her earnings for 2016 came from her Good American jeans and her salary for the reality show, Keeping Up with the Kardashians (2007).
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