- Son of former U.S. Senator Connie Mack, Republican, who served in the U.S. House of Representatives from Florida's 13th district from January 3, 1983 to January 3, 1989, and served in the U.S. Senate from January 3, 1989 to January 3, 2001.
- Mack graduated with a Bachelor of Arts degree from the University of Florida in 1993.
- Great-grandson and third namesake of Connie Mack, the long-time legendary owner/manager of the Philadelphia Athletics Major League Baseball team.
- Also through his father, he is the great-great-grandson of John Levi Sheppard (April 13, 1852 - October 11, 1902), who served two terms as a Democratic member of the United States House of Representatives for the Fourth Congressional District of Texas from March 4, 1899, until his death in 1902.
- Mack was a marketing executive between college graduation and his first run for U.S. Congress, including work as a consultant promoting Hooters Restaurants.
- Through his father, former US Senator Connie Mack, he is the great-grandson of John Morris Sheppard (May 28, 1875 - April 9, 1941), a Democratic United States Congressman and United States Senator from Texas. He authored the Eighteenth Amendment (Prohibition) and introduced it in the Senate, who was often referred to as "the father of national Prohibition." His service in the U.S. House of Representatives from Texas's 1st district was from March 4, 1903 to March 3, 1913. His service in the U.S. Senate was from February 3, 1913 until his death in 1941.
- (January 3, 2005 - January 3, 2013) U.S. Representative (R-FL).
- During his four terms in Congress, he was a member of the U.S. House of Representatives Oversight and Government Reform Committee.
- Was the Republican nominee, in 2012, for the U.S. Senate seat held by Senator Bill Nelson. Mack formally announced his campaign for the US Senate on November 28, 2011. In the November 2012 election, he lost to Senator Nelson.
- Grandson of Connie Mack Jr..
- With his former first wife, Ann Galluzzo, he has two children, a son named Connie Mack V, the fourth namesake of his great grandfather Connie Mack (in other words, his son is the fifth in a direct line of Cornelius McGillicuddy's), and a daughter named Addison Mack.
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