The film is considered to be the earliest Spanish horror film.
First installment of the saga that would continue 'Dr. Orloff's Monster' (1964), 'Orloff Against the Invisible Man' (1970) and 'Revenge in the House of Usher' (1983).
Howard Vernon continued to appear in a number of Franco's horror films up until his death In 1996.
A sequel to the film, titled El Secreto del Dr. Orloff and also directed by Franco, was released in 1964.
While filming his tribute to Hollywood musical films (Vampiresas 1930), director Jesús Franco convinced his producers to watch the British film The Brides of Dracula (1960). After the screening, Franco proposed that he could make similar films "in the same vein, but with a different style". Franco eventually convinced the same French co-producer who produced Vampiresas 1930.