Droopy is the famous British Detective Sherlock Droopy. He and Dr. Dripple do battle with the infamous professor Wolfiatity, their arch-nemesis. They stop him in Queen Victoria's bedroom.
Elliot Droopness and Son come face to face and baby carriage to baby carriage, with the arch criminal Babyman, in uncovering a series of unusual bank robberies.
Droopy, Master Detective and Dripple are called to the set of, "Queen of the Mutant Weirdo Vampires". Zuzu le Pew, the star of the film, threatens to quit unless she has protection and the villain is revealed.
Droopy, hired by a mysterious woman to find the stolen Dragon used in the Chinese New Year's parade, also finds danger from the villainous double of the mysterious woman.