In the Claire A Scenario Claire sees Leon on the security monitor and Leon isn't bandaged from the gunshot wound he received from Annette,
When Leon or Claire encounters the Licker in the hallway, the body of the decapitated cop disappears from the background also the door on the left (If facing the character when the Licker appears) is also missing.
Sherry is discovered in a room behind the chief's office, but before she got there, a helicopter crashes in a hallway blocking the only doorway to that wing of the RPD. So Sherry shouldn't of been able to get to that one room with the helicopter wreckage blocking the only way there.
At the near end of the A scenario in the final boss fight, the word "ELEVATER" on the floor is misspelled. It's suppose to have an "O-R" at the end of the word.
In FMV sequences Leon has a leg holster and leg belt around his right leg but in real-time cut-scenes and game play the leg holster is gone and the leg belt is around his left leg.
In FMV sequences Claire's belt around her shorts in brown but in real-time cut-scenes and game play its gray.
There's a part where your playing character hears a window crashing and zombies pour in after entering the library. But from the distance between the library and either of the two hallways where the zombies crash the window, you wouldn't be able to hear a window crash at all.