Director John Carpenter, who made the 1982 film of the same name that this video game is sequel to, worked closely with developer Computer Artworks. Such a good time was had all around that Computer Artworks got Mr. Carpenter to contribute his face and his voice for the in-game character of Dr. Shaun Faraday. Perhaps due to SAG considerations, however, the game's end credits only list a special thank-you message for Mr. Carpenter and not a voice actor credit.
Captain Blake says, "Now I'm gonna show you what I already know," before performing a blood test on himself. MacReady (Kurt Russell) says the same thing in The Thing (1982) before testing his own blood.
When Blake and his team find the UFO at the beginning of the game, the UFO is large and the cave where they find it is large enough for them to easily enter. In the movie however the UFO was no bigger than a bumpy car and the cave was small that McCready and the main characters had to squat to enter. Also the entrance to the cave was via a small hole/tunnel that the Blair-thing dug while trapped in the basement not through a mine opening as depicted in the game.