- The second film to be released in REAL D's digital 3D format.
- The film used 3D motion capture techniques to digitally record the physical performances of the actors before "skinning" them with their animated forms.
- The motto on the police car reads "We Wanna Help".
- For the Italian version of the film, Bones and Skull have been renamed "Punk" and "Freak".
- The wallpaper in DJ's room is the same design as Woody's shirt in "Toy Story".
- Homages to various Stephen King stories abound. The idea of a house that comes alive and eats people can be found in the third installment of King's "Dark Tower" series, "The Wastelands". And while in the house's basement, Chowder shines his flashlight on a mechanical monkey much like the one found in King's short story "The Monkey", collected in "Skeleton Crew".
- There are several references to both Steven Spielberg and Robert Zemeckis' films in 'Monster House': The toy monkey from Close Encounters of the Third Kind (1977). Trees that come alive is derived from Poltergeist (1982). The floating leaf at the beginning of the film is a nod to the falling feather from Forrest Gump (1994). And the basketball brand-named Wilson is a reference to the volleyball of the same name from Cast Away (2000).
- For the German version of the film, Bones, Skull and Chowder have been renamed "Punk", "Freak" and "Ketchup".
>>> WARNING: Here Be Spoilers <<<
Trivia items below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- SPOILER: To keep the movie a PG rating, the victims that were eaten (Bones, the cops and the dog) had to come back to life during the end credits.
- SPOILER: The poster at the circus for Constance's performance calls her "the woman as big as a house."
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