The kids who play Debbie and Pete's children are the real-life children of Leslie Mann and her husband, director Judd Apatow.
With the exception of Paul Rudd, the actors who play Ben's friends all keep their real first names for their character's names.
Originally to be a follow-up to The 40-Year-Old Virgin (2005), having Seth Rogen and company reprise their roles as the Smart Tech team.
Leslie Mann realized early on working with Paul Rudd that the way he argues in real life would drive her crazy. Rudd has a habit of making a flippant joke to break any tension, and this quickly got on her nerves. Judd Apatow realized very quickly the two would be perfect as an on-screen couple for this reason.
Stormy Daniels: a lap dancer. In April 2018, during an interview on The Ellen DeGeneres Show (2003), Seth Rogen said that while she was on the set of this movie, Daniels told him and others about her then-recent affair with Donald Trump. When the story of the affair emerged after Trump was elected US president, Rogen recalled that he'd heard Daniels's account of it a decade earlier. It was Trump's interactions with Daniels that led to him becoming, in March 2023, the first US president (current or former) ever to be indicted for a crime.