In this episode, Brenda (Shannen Doherty) has a breast cancer scare. In March 2015, Doherty revealed that she had breast cancer and in May 2016, she had a single mastectomy.
During the scene in which Dr. Donner explains Brenda's procedure to Jim and Cindy, a woman's voice can be heard on the intercom saying, "Dr. Rosin, please call extension three-fifty." This is a reference to executive producer Charles Rosin.