First episode to introduce 415 magazine and Prue starting her job as a photographer.
This is the second time Prue was in a car accident. The first time was in the season 1 episode "Dream Sorcerer" when she crashed her car into a pole.
The song that follows the Prologue, "Lucky" by Bif Naked, is also featured in an episode of Buffy in 1999. Many of the guest stars and soundtracks in Charmed are also popular on Buffy and its spin-off, Angel.
The title refers to Murphy's Law that broadly states, "if anything can go wrong, it will".
Daryl says that Maggie Murphy's description of the 'angel' that saved her bears no resemblance to Della Reese. This is a reference to the TV Series Touched by an Angel where Della Reese plays an angel called Tess.