Not all of Mama Lozupone's children are present at her deathbed. Carla has a younger sister named Annette, introduced in Season 2. Annette's absence is understandable: she was played by none other than Rhea Perlman.
First appearance of Gino Tortelli, who was first mentioned in Season 1's Truce or Consequences (1982).
Actress Sada Thompson. who plays Carla's mother, was best known for her role as a mother in the TV drama Family (1976).
Frasier mentions that his family were never close. This is revealed to be the case later in the series Frasier (1993) where he and his brother Niles had drifted apart and his relationship with his father Martin had always been strained.