Izzie and Cristina are assigned a close-to-brain-dead John Doe who may be a viable candidate for organ donation, and helpful to George's patient, who needs a new liver. Meanwhile, Meredith and Alex butt heads over a patient of their own.
A bike race injures several people, one of whom is left brain dead. Cristina and Izzie want to use his organs for organ donation, but they find the organ harvesting process an emotional one. Meanwhile, George deals with an over-flirtatious patient and Meredith has to deal with Izzie and George moving in, Alex showing off, and keeping Derek at arm's length.—Alex