The name of the pharmaceutical company, Taucher-Leto, comes from the names of two executive producers of the show.
Pilar Witherspoon has played three different roles over the course of the series:
- Episode 17.8 Melancholy Pursuit (2015) - Helen Ryan
- Episode 5.18 Careless (2004) - Julia Hynton
- Episode 5.2 Manic (2003) - Julia Hynton
- Episode 2.10 Consent (2001) - Officer Owens
Daniel Jenkins (Dr. Carl Medwin) previously played the role of Father Justin Miller in episode 7.11, Alien (2005).
BD Wong (Dr. George Huang) appeared in the Father of the Bride movies with Kieran Culkin, brother of Rory Culkin (Joe).