The cities mentioned in this episode (Cortland, Syracuse, Tully, and Binghamton) all lie along Hwy. 11 in central upstate New York. The use of these places is an homage by Rod Serling to his childhood. He was born in Syracuse and lived in Binghamton until he graduated high school. Even when he lived in Hollywood during his heyday, he maintained a home in Binghamton.
It was after filming this story that Martin Milner went to film Black November (1960), the pilot of the series which made him a star.
In the opening scene, the "LA" is blocked from the "LADIES" sign behind Millicent so that it reads "DIES."