With a tenth season, this series (temporarily) surpassed The X-Files (1993) as the longest running science-fiction series on American television.
When choosing the name, 'Adria', for her daughter, Claudia Black's character explains the name belongs to her "witch of a step-mother". Adria is the witch character from Blizzard's Diablo series of PC games.
Robert Picardo (Richard Woolsey) previously appeared in an episode of Star Trek: Voyager (1995) with the same title: Flesh and Blood (2000).