This is Doug Savant's final appearance as Matt Fielding.
In his last scene, Matt talks about his friend Rhonda for the first time since the end of the first season.
Alyssa Milano becomes an official cast member in the opening credits.
Linden Ashby joins the cast as Dr. Brett Cooper in this episode.
Linden Ashby previously played a different role, as Jo's ex-husband, in season one.