Hector Elizondo, who plays Callie's father, and Sandra Oh, who plays Cristina, previously worked together in The Princess Diaries.
"Elizabeth", one of the portraits Alex is showing to Jane Doe, is the real-life name of the actress Elizabeth Reaser.
Every episode of the show is named after a famous song. "My Favorite Mistake" is a song by Sheryl Crow.
The book Burke is reading towards the end when Christina arrives home is called "Dreaming of Bird" by Toussaint Banks. Banks worked on the crew and is most likely an allusion to this fact.
Michael Boatman, who guest starred in this episode, previously worked with Sandra Oh on the HBO series, Arliss.