Meredith deals with her over protective stepmother, Cristina is caught between Burke and Marlow, and Derek fights to become Chief. Meanwhile, Alex continues the search for Jane Doe's identity, and Izzie's past comes back to haunt her.
Meredith feels smothered by her father's wife, while Derek questions the Chief as to why he can't get the man's approval as his replacement. Alex thinks he's found the real identity to his Jane Doe and Izzy gets a request from out of nowhere, leaving her in shock and no George to turn to.—Moviedude1
It seems like just another ordinary day in Seattle Grace Hospital until tragedy strikes Izzie Stevens. To her dismay, the adoptive parents of her eleven-year-old daughter reveal a terrible truth. Her daughter is also a leukemia patient. Deeply saddened by this news, her daughter's adoptive parents also tell Izzie that she should donate some of her bone marrow to the girl. Because it is likely that it will be a "perfect match" ... Also the race to be "chief of surgery" tears Meredith and Derek's relationship apart.—Jake Halvari
Izzie faces her past and finds comfort in George, while Alex becomes more attached to Jane Doe, Meredith and Derek question their own status, and Cristina resolves to fight for her relationship with Burke -- despite her past with Colin Marlow.—ABCMediaNet