This episode features the song Busted, sung by Candace and Vanessa. Busted is one of the most famous/well-liked Phineas and Ferb songs.
"I Scream, You Scream" is the first episode segment where Dr. Doofenshmirtz appears before Major Monogram.
In the scene where Doofensmirtz is talking about eliminating things with his space laser he says he wants to eliminate morning talk show hosts. The picture of the two talk show hosts has a time stamp in the lower right corner. There is a typo in the time stamp. It's a semicolon ; instead of a colon :
Although This Episode Premiered In 2008 It Was Made In 2007 According To The Credits