Charlie tells Alan that Andy (Emilio Estevez) is like the brother he's never had. In fact, Charlie Sheen (birthname Carlos Estevez) and Emilio Estevez are real-life brothers.
Emilio Estevez's character is named Andy, the same name as his character in The Breakfast Club (1985).
Alan says Charlie never made a will and Charlie seems surprised Alan got the house. But in fact, back in season 4, Charlie tells Alan that he and Jake are in the will to inherit the house.
Charlie mentions the heart of darkness when describing one of the tests done at the hospital . The heart of darkness is the name of a documentary about the making of Apocalypse Now which starred Martin Sheen, Charlie's father.
Episode title spoken by Andy (Emilio Estevez), to Charlie.