The hallway that Flecks takes Ed Harley through in the Strater Hotel is the same hallway used in National Lampoon's Vacation (1983), where Clark Griswold robs the cash register at the Grand Canyon, and runs out. The interior used in that scene was the Strater Hotel in Durango Colorado.
Bill Smith, who plays Carl Coscarelli, in Face Eater, can be seen as an extra in Jaws (1975). He is in the background where Roy Scheider's character get slapped by the mother of the dead boy.
The lead redneck in the western gunfight scene is wearing a Johnny Cash t-shirt and a Deftones White Pony cap.
'Face Eater' has multiple characters that are named after famous horror/b-movie directors: John Carpenter, George A. Romero, Roger Corman, Tobe Hooper, David Cronenberg, Don Coscarelli and Wes Craven.