Dallas Roberts has played three different characters over the course of the series:
- Episode 5.11 Guardian (1995) - Matthew Blanchard
- Episode 11.16 Bronx Cheer (2001) - Mark Daltrey
- Episode 19.9 By Perjury (2009) - Marty Winston
Amy Hohn has played four different characters over the course of the series:
- Episode 5.7 Precious (1994) - Assistant M.E. Manning
- Episode 6.3 Savages (1995) - Assistant M.E. Manning
- Episode 7.16 Turnaround (1997) - Canton
- Episode 10.14 Entitled (2000) - Delia Woodruff
- Episode 15.4 Coming Down Hard (2004) - Laura Dixon
- Episode 19.9 By Perjury (2009) - Laura Dixon
Adam LeFevre has played seven different characters over the course of the series:
- Episode 19.9 By Perjury (2009) - Peter Belanger
- Episode 15.11 Fixed (2004) - Dr. Evodius Peters
- Episode 10.10 Loco Parentis (2000) - Barry Clayton
- Episode 8.16 Divorce (1998) - David Harrigan
- Episode 6.19 Slave (1996) - Barry Clayton
- Episode 3.6 Helpless (1992) - Dr. Helman
- Episode 2.7 In Memory Of (1991) - Joseph Kelly
- Episode 1.4 Kiss the Girls and Make Them Die (1990) - Bartender