Daniel Bryan's first Elimination Chamber win as a babyface.
Keith Lee was supposed to be in the triple threat match with Matt Riddle and Bobby Lashley for the United States Championship, but was pulled due to an undisclosed injury. A fatal four-way match was held on the Kickoff show to determine who will replace him. In the match, Morrison defeated Elias, Mustafa Ali, and Ricochet to win his way into the match later that night.
Elimination Chamber debut for Kevin Owens and Sami Zayn.
For the first time in the PPV's history, the Elimination Chamber structure was lifted from around the ring after each match was over while the winner of the match was still in the ring, and then both EC winners ended up in a match immediately afterwards for each respective men's world title. (Daniel Bryan faced Roman Reigns for the Universal Championship as it was part of the stipulation for the SmackDown match, and Drew McIntyre faced The Miz for the WWE Championship when The Miz cashed in his Money in the Bank contract.)
The first Elimination Chamber PPV without a women's EC match since 2017.