- Dr. Meredith Grey: [opening voiceover] When something begins, you generally have no idea how it's going to end. The house you're going to sell becomes your home, the roommates you were forced to take in become your family and the one night stand you were determined to forget becomes the love of your life.
- Dr. Meredith Grey: [closing voiceover] We spend our whole lives worrying about the future, planning for the future, trying to predict the future, as if figuring it out will cushion the blow. But the future is always changing. The future is the home of our deepest fears and wildest hopes, but one thing is certain when it finally reveals itself, the future is never the way we imagined it.
- Dr. Alex Karev: [to Izzie] Look, you went crazy. When Denny signed that DNR, you went crazy. Is that what you want? You want me cutting LVADs?
- Dr. Izzie Stevens: No.
- Dr. Alex Karev: You want to wreck my career? Because I will! I will freaking cut LVADs before I let you just... just wait! Stop!
- [they stop pushing the gurney]
- Dr. Alex Karev: You don't get to quit. You don't get to quit on me. Please. Tear it up. The DNR. Tear it up!
- Dr. Izzie Stevens: Where your eyes are supposed to be right now, I see white, sandy beaches. And there's an ocean behind your head, and there are ghosts wandering in and out. I can't live like this. And I can't live if something goes wrong in that surgery. I don't want any extraordinary measures taken to keep me alive. It's not what I want. I went crazy when Denny signed the DNR because I didn't understand. I didn't understand, but now I do and I need you to understand. I don't want you to go crazy. I want you to have a brilliant career and I hope that I get to be there for that, but if I can't, I... I just want to go to the other side. I don't know what's there, but it's got to be better than hospital beds and tubes down my throat. Please. Please don't cut LVADs. Just... if it comes down to it, just let me go. And right now, kiss me. Please, please just kiss me and close your eyes because the beach is so distracting.
- Dr. Alex Karev: [crying] Alright.
- [kisses Izzie]
- Alison Clark: [to Izzie] Don't do it. That's my vote. Don't have the surgery. I didn't. I frigging hate surgery.
- Dr. Izzie Stevens: I'm hallucinating, Allison. I have really long conversations with dead peopl and I see that aren't... Like right now, for example, I'm pretty certain there aren't birds flying over your head, because this is a hospital and that would be weird. But, that's what I'm seeing. I have a brain tumor. Am I really not gonna let them cut it out?
- Alison Clark: I didn't let them cut out mine. It's like... Okay, one minute, I'm this college kid, rowing crew, and being an idiot, and forgetting to bring my sunscreen, and thinking it doesn't matter. Because, I'm me, and life has turned out pretty good for me. And then the next minute, they're cutting into my body every other week. I had 15 surgeries, and then I said... enough. Forget it. I'll rogue through in heaven, or whatever. And then, the IL2 worked. It worked. I come here every 3 weeks, I get my medicine and I don't have a brain tumor anymore.
- Dr. Arizona Robbins: Chief.
- Dr. Richard Webber: Did you wanna tell me something?
- Dr. Arizona Robbins: I am going to cry, and I just want you to know that I know it's going to happen. And I just want you to ignore it. And I'm not crying because I'm upset. It's just what happens when I get mad at people of authority.
- Dr. Richard Webber: You're mad at me?
- Dr. Arizona Robbins: [starts crying] I am mad at you. And I'm crying because you're the boss. My boss, which brings up issues of authority and my dad, who you kind of remind me of. Not that you're old, but you command respect. People respect you. I mean, I know I do and I know Bailey does. Which is why I'm mad. Because, it's wrong, sir. It's wrong and mean to use a robot to lure Dr. Bailey back into general surgery because I don't have a robot. All I have are little kids, and they're not as fun as a robot. And they're not shiny, and new, and silver, and they don't have things coming out of their belly buttons. But I will fight you, and I will win, sir.
- Dr. Richard Webber: You think you can fight me and win?
- Dr. Arizona Robbins: Yes!
- Dr. Richard Webber: Good luck.
- Dr. Arizona Robbins: Because I have something that you don't have! I have joy, sir!
- Dr. Alex Karev: [to Izzie] You're having the surgery.
- Dr. Izzie Stevens: What?
- Dr. Alex Karev: Shepherd said that this is your last shot.
- Dr. Izzie Stevens: Look, I under...
- Dr. Alex Karev: I am your husband, and I say that you are having the surgery!
- Dr. Izzie Stevens: What happened to "this is your decision."?
- Dr. Alex Karev: That was when I thought you were gonna make the right one! But you chose wrong, so now you don't get to make this decision on your own because you married me! It's not just your life at stake anymore! It's my life, too. My life with you! So you can tell Swender whatever you want, but I'm telling Shepherd, and I'm telling you that you're having the surgery!
- Dr. Owen Hunt: I realized the reason why I haven't told my mother I'm back is because part of me is still over there. I made a commitment to the Army that I wasn't able to fulfill. If my unit hadn't been destroyed, I would still be there. So, no wonder I can't sleep at night or look my mother in the eye. No wonder you and I, we can't move forward. My work there isn't done. Until it is, I have no business being here, so I've decided to go back.
- Dr. Cristina Yang: I have to go.
- Dr. Owen Hunt: Cristina.
- Dr. Cristina Yang: What?
- Dr. Owen Hunt: Come on.
- Dr. Cristina Yang: I'm sorry. What am I supposed to say?
- Dr. Owen Hunt: I could use your support.
- Dr. Cristina Yang: You don't have it.
- [walks away from Owen]
- Dr. George O'Malley: Izzie? You paged me. Are you okay?
- Dr. Izzie Stevens: No, I don't know what to do. I don't know if I should have the surgery. I think I'm gonna die either way. You gotta tell me what to do.
- Dr. George O'Malley: You know what to do.
- Dr. Izzie Stevens: No, I don't. I don't.
- Dr. George O'Malley: Yes, you do. You're just scared to do it. This back and forth is just fear. You've already made the decision. You made it. You made it the second you decided to fight this thing. Just look, look where you started. Look where you are now. I mean, now you're this incredible surgeon, and teacher. You're a doer, remember? You know exactly what you have to do.
- Dr. Izzie Stevens: [to Derek] You can do it. You can cut into my brain again.
- Dr. Derek Shepherd: Okay.
- Dr. Izzie Stevens: You can do it, but I don't wanna end up a vegetable.
- Dr. Derek Shepherd: Izzie, you won't.
- Dr. Izzie Stevens: No, just listen. I want the surgery right now, but if something goes wrong, I don't wanna end up on a ventilator, so I'm signing a DNR.
- Dr. Cristina Yang: [to Owen] God, it doesn't matter how good you are. Or how hard you work. You can do all the research, you can master all the latest techniques, I mean you can be the best. You can be the best surgeon in the world, but your patients are still gonna die 'cause the next day or the next month, or the next year, you know they're just gonna get hit by a car or find a mole on their back. There's nothing you can do about it.
- [looks at Owen]
- Dr. Cristina Yang: I don't want you to die.