Rob Zombie shot the film with a heightened color scheme. "I noticed when the actors were in their makeup and they were just walking around, getting lunch or whatever, they looked like cartoon characters come to life. They were just so insanely colorful. I had to light the movie in the same fashion. It really seemed at all times like a live action cartoon, which was really exciting."
Original Munsters actors Butch Patrick and Pat Priest have voice cameos in the film. Butch, who played Eddie in the original series, is the voice of the Tin Can Man. Pat, who played Marilyn in the original series, is the voice of the Transylvania Airlines announcer.
Real estate agent Barbara Carr is played by Cassandra Peterson, who is best known for portraying Halloween icon Elvira, Mistress of the Dark.
Rob Zombie's first movie not to be rated R.