When Peter introduces Tiffany and says he is going to have sex with her, Tiffany says that he doesn't have to worry about getting her pregnant because she is already pregnant. At the time this aired Tiffani Thiessen was four months pregnant with her first child.
The hippocampus is a structure in the brain essential to storing long-term memories. Damage to the hippocampus can cause anterograde amnesia, an inability to store new permanent memories.
A tape of "Pretty Woman", Gene Siskel's review mentions headaches and doctors and awaiting results. In 1999 Gene Siskel was diagnosed with a brain tumor and soon after died from post-operative complications.
During the Family Feud (1976) segment, host Richard Dawson tells Peter that he "served in the fictitious military", in reference to Dawson's character in Hogan's Heroes (1965). While Dawson was not in the military per se, he did however serve in the British Merchant Navy in both World War II and the Korean War.
The title spoofs the stereotype of the star athlete or most popular student at college: Big Man on Campus (B.M.O.C.).