The full budget of the movie is less than 3.5 million dollars which was Nicolas Cage's salary for Left Behind (2014)
Kevon Sorbo's character, Rayford Steele, sees "god is dead" spray painted in the church. Kevin Sorbo played a character in the movie, "God's Not Dead" where he is a professor demanding that his students write "God is dead" on a piece of paper.
This is the sixth Left Behind movie, after the original trilogy, the 2014 reboot, and the 2016 spinoff.
The first draft of the script was completed in 2017. Before filming began in 2021, there were significant rewrites in order for the story to better reflect then-current events.
Following Left Behind (2014), Chad Michael Murray, Cassi Thomson and Nicky Whelen were under contract to reprise their roles for two sequels. However due to the length of time between projects as well as scheduling conflicts, Rise of the Antichrist ended up with a complete recast.