This was the first original episode broadcast on Comedy Central.
The club that Fry, Leela and Bender go to is Studio 1 squared, 2 to the power of one, 3 cubed. It's obviously a parody of Studio 54, because its name equals 54 (1^2=1, 2^1=2, 3^3=27. 1*2*27=54).
There is a seven year gap in between the last episode of season five being aired on Fox, who canceled the show in 2003, and this first episode of season six being aired on Comedy Central in 2010.
The 52 Comedy Central episodes, starting with this one, are actually considered to be four seasons of 13 episodes each, counted as seasons 7-10. The four direct to video movies, broken up into four episodes each, for a total of 16 "episodes" is considered to be season 6.