Hermes pops a pill when he says he has a hankering for a useless remedy created by a schoolteacher. The name on the bottle is Airbunk, a joke reference to the Airborne dietary supplement created by schoolteacher Victoria Knight-McDowell in the early 1990's. The effectiveness of the supplement was sketchy at best and the company was sued for false advertising.
Josh Gedgie is seen wearing a t-shirt labelled "YP17," a reference to the term "yellow pigs" which appears as an Easter Egg in mathematics textbooks by Michael Spivak and refers to the mascot and favorite number of the Hampshire College Summer Studies in Mathematics (HCSSiM), a long-running summer program for talented mathematics students at Hampshire College.
When Yancy and Fry are wrestling, Fry shouts "My underbite!" Matt Groening's drawing style for most of the characters on Futurama (as well as The Simpsons) have a very prominent overbite. Fry's overbite is one of the most prominent in this series.
When Surgeon General Wernstrom shows Earth President Nixon the virus-spreading projections, the global projection shows the earth spinning westward, as it has since the events of That Darn Katz! (2010).
Among the ancient satellites dumped on Enceladus in 2113, was a UPN (United Paramount Network) satellite. The UPN was a television network broadcasting from 1995 to 2006. Apparently, the defunct network's satellite remained in orbit for over 100 years before the 2113 space junk cleanup.