The café where Richard Webber is having coffee in the beginning of the episode is called "The Rhimes Café" after the producer of the show, Shonda Rhimes.
Ellen Pompeo's favorite episode according to her from the Payley Fest 2017 Grey's Anatomy Panel.
This episode is tied with "Death and All His Friends" as the highest rated episodes of the series as of April 2021.
Gary Clarks wife is named Allison. When Izzie had cancer, she had a fellow cancer patient friend who's name was also Allison Clark.
Gary Clark was also the name of the patient from "New History" who had a cardiac problem, and whom Cristina and Teddy fixed.