The ending fight between Rex and the Slug EVO is similar to FEAR 2: Project Origin. The protagonist of the series (Rex and Michael Becket) is forced to fight off a jealous enemy (the Slug EVO and Harold Keegan), who demands to know throughout the fight why "she" (Breach and Alma Wade) prefers the protagonist over them. During both fights the camera cuts out to the woman in question screaming out and end with the woman appearing to implode and disappear, only to be revealed to be still alive later on. Both women have black hair that covers their eyes and have an extreme attachment to their respective protagonist.
This episode has what appears to be many nods to the Silent Hill video game series.
On iTunes, the episode is titled "Into the Breach."
When Doctor Holiday first shoots a probe at Breach, she says that the portal Breach created was a reflex. Dr. Holiday follows her observation by saying "Remember that "no touching rule"? Would have made a big mess had I been wrong." However, since she was correct about avoiding contact with Breach, this statement is incorrect. (A "big mess" would have been if the agents didn't listen to her warning).