Every episode of the show is named after a famous song. "That's Me Trying" is the title of a song performed by William Shatner.
Both Wynn Everett and Amber Benson appeared in Supernatural. Wynn played Amelia Novak and Benson played the vampire Lenore.
Jessica Capshaw (Arizona Robbins) is pregnant during this episode. Her story arc of going to Africa was likely written as a way to account for her being missing from the show during her maternity leave.