The title refers to the suave, well dressed assassin "The Handsome Man" portrayed by R&B singer Ne-Yo (a.k.a. Shaffer Smith). In August 2012 Ne-Yo performed the Michael Jackson hit song "Smooth Criminal" at a concert held in New York City to honor Jackson on what would have been his 54th birthday, August 29.
The song at beginning of the episode is "Beautiful Monster" by Ne-Yo, who also guest stars as "The Handsome Man" in this episode.