At 26 years old, Sarah Weddington stands in a courtroom for the first time in her life and argues the most explosive case of her era: Roe V. Wade. Supreme tells her unlikely story, as well as that of Justice Harry Blackmun, who's appointed to the High Court at the same time. Sarah and Harry - both new, untested, and scared out of their minds - are on a collision course. She struggles to overcome the many obstacles placed in her path, while he must find the courage to step out of his lifelong best friend's shadow and take a stand. Together, they create one of the defining moments of the century.