David Strathairn plays a CIA Director in the series. He also played a CIA Director in The Bourne Ultimatum (2007) and The Bourne Legacy (2012).
Ron Perlman's character calls Reddington "Red." Ron Perlman played Hellboy in Hellboy (2004) and Hellboy II: The Golden Army (2008) whose code name was "Red."
The character of Kat Goodson (Deputy Director of the National Clandestine Service) has almost the same name as co-producer Katrin L. Goodson.