Cisneros is Queen Isabel's right hand man in 1491, but he did not join the royal court until 1492.
The coat of arms in the throne room bears the arms of Granada, which weren't added until its conquest in 1492.
While dining with Amelia's parents in 1880, Julián says that there will be a new war in Cuba soon, which surprises Amelia's father. The Second Cuban War actually broke out in August 26, 1879, more than enough before, for news to have reached Amelia's father already.
Amelia's father asks Julián, in 1880, about his opinion on the agreement between Cánovas and Sagasta to succeed each other as prime minister cyclically. This agreement was not made until 1885.
Levi claims to have healed nine-year-old Isabel in Aranda. When Isabel was nine (in 1460), she was imprisoned in Arévalo under orders of King Henry IV of Castile, 128 km away.