JJ's story about Rosemary Kennedy is true. Her lobotomy was among the first performed. It was unsuccessful and left her severely mentally and physically handicapped. She was institutionalized for the rest of her life and didn't see her parents or family for twenty years after the lobotomy. She never regained the ability to speak clearly.
This is Paget Brewster's first appearance as a series regular since the season seven finale, Run (2012).
Sherilyn Fenn, the actress who plays the mother, was on Friends (1994) where she dated first Joey and then Chandler. Paget Brewster (Prentiss), was also on Friends and dated Joey first and then Chandler. Aisha Tyler also appeared on Friends, first dating Joey, then Ross.