In Awl (2016), MacGyver carries a bag that has the writing Mission City Star. According to the original show character biography Angus MacGyver was born and raised in Mission City, Minnesota.
Riley roughly translates the doctor's reaction as 'Screw you guys, I'm goin' home.' This is a catchphrase often used by Cartman in South Park (1997).
When Ralph Kastrati, the hedge fund guy, tries to pay-off Jack & MacGyver he offers to also "throw in a Wu-Tang album". This is a reference to real-life hedge fund manager Martin Shkreli (infamous for his wild price-gouging on a life-saving AIDS medication). In 2015, he spent some of his fortune buying the only known copy of Wu-Tang Clan's album "Once Upon a Time in Shaolin" for reportedly around $2 million USD.