This is the first episode of the series to feature only Supergirl and not Kara Danvers.
Cat Grant also appeared in the first season of Lois & Clark: The New Adventures of Superman (1993), and was an antagonistic foil to Teri Hatcher's Lois competing for Clark's affection.
It is the second episode to feature both a former Lois Lane (Teri Hatcher) and Diana Prince/Wonder Woman (Lynda Carter).
Lynda Carter's previous television appearance along with a "Superman" actor was in Smallville's sixth season episode "Progeny" as Chloe Sullivan's mother, Moira. However, she and Tom Welling were not onscreen together.
In the beginning of the season when Supergirl finds out about the new DEO locations, J'onn tells her that this is one of many secret locations the DEO owns. Yet, when the daxamites attack they retreat to a dive-bar.