Wyatt makes the comment at the end of the episode, "You can call it fate, or God, or the Force..." Lanter would know all about the Force, as he is the voice of Anakin Skywalker in both Star Wars: The Clone Wars (2008) (the film) and Star Wars: The Clone Wars (2008) (the series).
Jim Beaver, who plays the new NSA agent in charge, is also known for being on Eric Kripke's other production Supernatural (2005) as Bobby Singer, the Winchesters' surrogate father.
Actor Jesse Luken (playing Charles Lindbergh) was also in Star-Crossed (2014) with Matt Lanter (Wyatt Logan).
The remark that is made to Ernest Hemingway in 1927 Paris about having read all his books when he at the time had published only one is a direct quote from Woody Allen's Midnight in Paris (2011), when Owen Wilson says the same thing.
As of 2022, both Susanna Thompson and Annie Wersching have played a version of the Borg Queen in a Star Trek franchise - Thompson on Star Trek: Voyager (1995) and Wersching on Star Trek: Picard (2020).