Grim Fandango is most definitely the best title of its Genre EVER! You play the part of Manny Calavera a travel agent of death selling nothing but poor travel packages for the long journey to the 9th underground to his recently passed away clients, but Manny senses crime and corruption in the department of death when he find that his associate Domino gets all the good clients and Manny is stuck with all the poor clients. In my honest opinion Grim Fandango is the best title of its genre. Of course there are downsides like the long loading times between scenes and controlling Manny can be difficult at times but it doesn't get in the way of it's great storyline.
Review of Grim Fandango
