In Mexico there is a cult that is rapidly growing- the cult of Saint Death. This female grim reaper, considered a saint by followers but Satanic by the Catholic Church, is worshiped by people whose lives are filled with danger and/or who don't feel accepted by the church- criminals and gang members, sick people, drug addicts, gays and transsexuals and families living in rough neighborhoods. Narrated by Gael García Bernal, "La Santa Muerte" examines the origins of the cult and takes us on a tour of the altars, jails, and neighborhoods in Mexico where the saint's most devoted followers can be found.